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Part I: Personalia First Name: Kristel Place of birth, Date: Dendermonde, 3 June 1969 Address

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Part I: Personalia First Name: Kristel Place of birth, Date: Dendermonde, 3 June 1969 Address



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Research topics in mathematics included:

Affine and Euclidean building theory

Finite geometry

Trees


(Algebraic) Topology

Conclusions in these domains are the result of pure reasoning, starting from a set of basic assumptions. My academic activities as a researcher in fundamental mathematics (from 1/9/1994 to 31/1/1998) mark a period of further development in logical and structural thinking.




Overview 3rd cycle educational training – Orientation Mathematics:


  • Training ULBrussel, 10 May 1996 (3 lectures):

  • Training RGhent University, 1994-95 (7 lectures).

  • D(iscrete) A(lgebra and) G(eometry) days (1993-1995).

  • 3rd cyclus NFWO, KUL-Ghent University: Linear algebraic groups (1992-1993).

  • 3rd Cyclus: Buildings UL/Brussel (1992-1993).

  • Sommerschule Gebäude. Bielefeld University (Germany) 8-15 September 1991.



Reference:

Prof Dr H Van Maldeghem

Vakgroep Zuivere Wiskunde en Computeralgebra
Ghent University
Galglaan 2
B-9000 Ghent

e-mail: hvm@cage.ugent.be





  1. Know-how 2: Education and development


Experience at the ULg
2010-2011


code

Description

Cycle

# students

EPID0754-1

Introduction à l’épidémiologie génétique

EPID0754-A-a 20h Th, 20h Pr



2

5

GBIO0009-1

Bioinformatique

GBIO0009-A-a 30h Th, 30h Pr



2

10

GBIO0015-1

A tour in genetic epidemiology

GBIO0015-A-a 15h Th, 15h Pr



2

1

MATH0008-2

Introduction au calcul des probabilities et à l’analyse statistique

MATH0008-A-b 15h Th, 15h Pr



1

166


2009-2010


code

Description

Cycle

# students

EPID0754-1

Introduction à l’épidémiologie génétique

EPID0754-A-a 20h Th, 20h Pr



2

4

GBIO0001-1

Introduction au génie biomédical

GBIO0001-A-a 30h Th, 30h Pr



1+2

23

GBIO0009-1

Bioinformatique

GBIO0009-A-a 30h Th, 30h Pr



2

11

GBIO0015-1

A tour in genetic epidemiology

GBIO0015-A-a 15h Th, 15h Pr



2

3

MATH0008-2

Introduction au calcul des probabilities et à l’analyse statistique

MATH0008-A-b 15h Th, 15h Pr



1

163


2008-2009


code

Description

Cycle

# students

ELEN0441-1

A tour in genetic epidemiology

ELEN0441-A-a 15h Th, 15h Pr



2

5

EPID0754-1

Introduction à l’épidémiologie génétique

EPID0754-A-a 20h Th, 20h Pr



2

7

GBIO0001-1

Introduction au génie biomédical

GBIO0001-A-a 30h Th, 30h Pr



1+2

24

GBIO0009-1

Bioinformatique

GBIO0009-A-a 30h Th, 30h Pr



2

16

GBIO0015-1

A tour in genetic epidemiology

GBIO0015-A-a 15h Th, 15h Pr



2

2


2007-2008


code

Description

Cycle

# students

GBIO0001-1

Introduction au génie biomédical

GBIO0001-A-a 30h Th, 30h Pr



2

33



Other experience in teaching


  • Short course: Genome-wide association studies (with co-teacher Andreas Ziegler – University of Luebeck/Germany) – Brazil (Dec 2010).

  • Short course: Gene-gene and gene-environment interactions – An overview of methods and available software, UMCG, Groningen – the Netherlands (8 May 2009)

  • Short course: Family-based designs in genetic association studies, UVic – Spain (30 June, 2008).

  • University teacher and responsible for courses in statistics (3rd Bachelor Dentistry; Medische Statistiek en Methodologie van Onderzoek, Ghent University, Ghent, Belgium (2006-2008).

  • University teacher and responsible for Statistical Genetics, Master of Statistical Data Analysis, Ghent University, Ghent, Belgium (2005-2006; 2007-2008).

  • University teacher and/or responsible for modules in statistics (2de Bachelor in Mathematics; “Kansrekenen en wiskundige statistiek”, Ghent University, Ghent, Belgium 2005-2008).

  • Short course: FBAT/PBAT course in Europe; Institute of Biology, Lille – France (March 30-31, 2005).

  • Short course: Using FBAT and PBAT to Analyze Family-Based Association Studies in Genetics; Harvard School of Public Health (HSPH) Boston – VS (January 24-26, 2005).

  • Short course: The Analysis of Family Based Association Studies in Genetics; Department of Medical Epidemiology and Biostatistics (MEB) Karolinksa Institutet, Stockholm - Sweden (March 24-26, 2004).

  • University teaching assignments for different modules in statistiek (Calculus for Statistics, Multivariate Techniques, Statistical Reading) Master of Applied Statistics Program Hasselt University, Diepenbeek, Belgium (1999-2002).

  • Assistant for the practical training sessions in “analyse, lineare algebra en analytische meetkunde”, Bachelor of Science Program, Ghent Univeristy, Ghent, Belgium (1993-1997).

  • Assistant of introductory summer courses for students in civil engineering, fysics, mathematics and informatics: “meetkunde en algebra”, Ghent University, Ghent, Belgium (1992-1996).



Realization of supervised self-study and development of didactical tools
I have a shared responsibility in work package WP 1.1. of the Global Allergy and Asthma European Network GA2LEN with the Charité (Germany) in particular for the part on e-learning and e-testing. To create an extensive compendium of useful material I worked out new goals for the 4th work year of GA2LEN on e-learning and e-testing and created the basis for an Instructional Design template to be used for pre- and post-testing knowledge during future GA2LEN Allergy Schools.
A reflection of aforementioned activities is highlighted in the publication “Education via E-testing” in GA2LEN News – Spreading excellence in allergy and asthma, nr 10, devoted to “Creating excellence through education & training” (http://www.GA2LEN.net//files_new/filesPublic/Publication_GA2LEN%20News10.pdf).
Reference éducation:

Prof Dr J A Thas

Vakgroep Fundamentele en Computergerichte Wiskunde
Ghent University
Galglaan 2 B-9000 Ghent

e-mail: jat@cage.ugent.be


Reference E-learning à GA2LEN:

Prof Dr T Zuberbier

Charité - Universitätsmedizin Berlin
Klinik für Dermatologie, Venerologie und Allergologie
Charitéplatz 1
D - 10117 Berlin

e-mail: torsten.zuberbier@charite.de


During my professional activities I have been giving both basic and specialized courses. Self-study became increasingly important. This explains my search for alternative educational tools that stimulate self-study, but simultaneously allow for fast detection of problems and accurate interaction.

Participation in committees and working groups with respect to education


  • Task force group to reorganize Probability / Statistics / Stochastics in the Bachelors of the Engineering curriculum (with L Wehenkel and V Denoël)

  • Work group to create a new “Masters in Epidemiology” at Antwerp University (responsible for programme item “Genetic epidemiology”). Start of group activities: 2010

  • Collaboration set up between the University of Maastricht (R Westra) and the University of Liège concerning giving guest-lectures within the corresponding existing bioinformatics programs. Practical start: academic year 2010-2011

  • Secretary of the Educational Board – Biomedical Civil Engineering (Ulg; 2008-2009, 2009-2010)

  • Member of AIM, Association des Ingénieurs de Montefiore (2008 -)

  • Learning from data project: coordination of practical implementation, Hasselt university in close collaboration with University of Maastricht (the Netherlands) 2002



Thesis supervision
Doctorate
Thesis jury member (since 2008)


  • Carolien Bettens (Antwerp University); Topic: The genetic architecture of Alzheimer disease: in search of risk factors (21 October 2010)

  • Hugues Aschard (INSERM, France; student of Florence Demenais); Topic: Analyses multi-marqueurs et multi-phénotypes dans les études génétiques des maladies multifactorielles – exemple de l’asthme dans l’étude EGEA (3 December 2009).

  • Michel Journée (Liège University); Topic: Geometric algorithms for component analysis with a view to gene expression data analysis (4 June 2009).

  • Erik Quaeghebeur (Ghent University, Belgium; student of Gert de Cooman); Topic: Learning from samples using coherent lower previsions — Leren uit monsters met coherente onderprevisies (23 Jan 2009).


Thesis committee member (depuis 2008)


  • Wambo LI (doctorat en sciences vétérinaires - promoteur Michel Georges) - membre de comité de thèse depuis 16 Nov 2010

  • Gaëlle Marenne (CNIO, Spain; student of Nuria Malats and Emmanuelle Génin) ; Titre provisoire: Identification and development of tools to perform association analysis using the joint information on CNVs & SNPs with an application on the data of the Spanish Bladder Cancer (SBC)/EPICURO Study

  • Olivier Stern (Liège University : Faculté des Sciences Appliquées) ; Titre provisoire : Intégration de données génomiques et protéomiques et de banques de connaissances biologiques pour la découverte de biomarqueurs et la biologie systémique

  • Vincent Botta (Liège University : Faculté des Sciences Appliquées) ; Titre provisoire : Apprentissage automatique appliqué à la génomique.



Diplôme d'Études Approfondies committee member (depuis 2007)


  • Zhiyang Zhang (GIGA, Liège University); Titre: Marker imputation with low-density marker panels in Holstein cattle (2009-2010)

  • Vincent Botta (Liège University : Faculté des Sciences Appliquées) ; Titre : Prédiction du risque génétique par apprentissage automatique supervisé dans le cadre des maladies complexes (2007-2008).


Promotor of doctoral students (since 2006)


  • François Van Lishout (Liège University); Titre provisoire : TBA – promotor (with L Wehenkel)

  • Jestinah Mahachie (Liège University); Titre provisoire : Des méthodes de screening des associations génétiques pour des données complexes et multidimensionelle - promotor

  • Lizzy De Lobel (Ghent University); Titre provisoire : Alternative methods to detect gene-gene interactions - promotor.

  • Peter Konings (Catholic University Leuven); Titre provisoire : Identification and analysis of CNVs in human genetics - copromotor.

  • Jeroen Huyghe (Antwerp University); Titre: Identification of genes contributing to human complex diseases and traits in the genetically isolated Saami and the general European population- copromotor. Thesis defended April 6, 2011.


Statistical consulent of doctoral students (since 2004)


  • Marie Joossens (Catholic University Leuven); Topic: Gut microbiota in relation to Crohn’s disease. Doctoral thesis defended in 2010.

  • Ingrid Arijs (Catholic University Leuven); Topic: micro-array analyses of Crohn patients prior to and after therapy. Doctoral thesis defended in 2010

  • Marieke Pierik (Catholic University Leuven); Topic: Susceptibility to inflammatory bowel diseases and pharmacogenetic predictors of treatment outcome in the Flemish population. Thesis defended in 2006.

  • Olga Bijnens (Hasselt University); Topic: Het gebruik van cycloongas en staalgrit bij de “in situ” immobilisatie van metaalgecontamineerde bodems: een statistische benadering. Thesis defended in 2006.


Master
Jury/committee member (since 2008)


  • Jean-Yves Nicolas ; Topic : Identification de signatures multiples par ensemble d'arbres de décision. Thesis defended in 2010-2011

  • Arnaud Joly ; Topic : Amélioration des forêts aléatoires dans le cadre de problèmes à très haute dimension. Thesis defended in 2010-2011

  • Sébastien Roland; Topic: Prioritisation de gènes par ensembles d’arbres de decision. Thesis defended in 2009-2010

  • Aline Serteyn; Topic: Wearable ECG-monitor for real-time epileptic seizure detection. Thesis. defended in 2009-2010

  • Stéphane Wenric; Topic: Complétion du réseau OMIM par apprentissage automatique. Thesis defended in 2009-2010

  • François Ghilain; Topic: Algorithmes de réduction de données transcriptomiques temporelles. Thesis defended in 2008-2009


(Co-)Promotor of master students
ULg TFE faculty of applied sciences (since 2008)


  • Thomas Leysen; Titre provisoire: Efficient genome-wide two-locus epistasis testing in disease association studies (on Erasmus Exchange from ULg to University of Vic. Promotor at host institution: Malu Calle). Thesis to be defended in 2010-2011

  • Jose Rial; Titre provisoire: Association testing in the presence of gene-gene interactions : MB-MDR compared to BOOST (on Erasmus Exchange from computer science at the University of A Coruña, in Spain, to ULg). Thesis to be defended in 2010-2011

  • Arnaud Blanjean; Titre provisoire : Random Jungle for statistical genetics. Thesis to be defended in 2010-2011

UHasselt Master of Science in Biostatistics




  • Dominik Grathwohl; Topic: A Model-Based 40 to 1 Algorithm in Microarray Analysis. Thesis defended in 2002.

  • Chris Muller; Topic: The EigenApples Approach. Thesis defended in 2002.

  • Mbah Alfred Kubong; Topic: Growth of Dutch PKU Patients. Thesis defended in 2002.

UHasselt Master of Science in Applied Statistics




  • He Liang; Topic: Dealing with Discreteness: Confidence Intervals for Difference in Proportions. Thesis defended in 2002.

  • Petra Goyens; Topic: Evolution and Effect of Trans Fatty Acids during Pregnancy. Thesis defended in 2002.

  • Valerie Poulart; Topic: Checking for proportional hazards assumption in survival studies. Thesis defended in 2002.

  • Maarten Borremans; Topic: The comparison of DNA sequences using a Mahalanobis-type distance measure: a sensitivity analysis? Thesis defended in 2001.

  • Nahson Sigalla; Topic: Sampling Schemes for Large Units (co-supervisor). Thesis defended in 2001.

  • Anthony Gichangi; Topic: Missing data in the health interview survey 1997. Thesis defended in 2000.



  1. Know-how 3: Communication and knowledge dissemination


Dissemination of research and science


  • Via involvement in GA2LEN, in particular WP 1.1

  • Via research activities

  • Via involvement in BioScope-IT, a FlandersBio's Bioinformatics Service Project to reduce the gap between Flemish biotech companies to implement bioinformatics applications.


Press reports of scientific research, targeting a non-scientific audience


  • "In Utero Smoke Exposure and Impaired Response to Inhaled Corticosteroids in Children With Asrhma." (Ulg REFLEXIONS, February 2011)

  • “ ‘StepGen’ nieuwe spin-off ” (Maandblad Gent Universiteit, June 2008).

  • “UGent lanceert nieuwe medische spin-off” (Trends, 17 April 2008).

  • “ ‘StepGen’ nieuwe spinoff van de UGent” (UGent Press Release / Technologie Transer, 9 April 2008).

  • “Statistical method provides unprecedented look at genetic underpinnings of complex diseases” – appeared in Harvard School of Public Health Press Releases, after an interview by Christina Roache of the HSPH press department with Dr C Lange and myself.

  • “Een massa gegevens” - appeared in Knack, Mens & Cultuur 3, nr 28-29, 13 - 26 July 2005. This publication was composed by D Draulans on the basis of a text proposed by myself.



Overview 3rd cycle educational training – Orientation Communication


  • Advocacy workshop on developing the basic skills of doing advocacy and lobbying work (Miriam Stein, lobbyist with Cooperative Metropolitan Ministries) Newton (USA) 16 May 2005.

  • Biotechnology project management, spring term course organised by the Harvard Extension School and the Massachusetts Biotechnology Council, 2005

  • Inter-university doctoral training: Wecom – orald and written scientific communication, Hasselt University, 2002.

  • Interculturele Communicatietraining, Hasselt University, 6-7 September 2001.



Reference Biotechnology Project Management:

Lydia Harris, MGA,

Co-Chair of the Project Management Committee,

Massachusetts Biotechnology Education Foundation,

Massachusetts Biotechnology Council.

E-mail: lydia_harris@massbio.org




  1. Know-how 4: Biostatistics


Research topics in biostatistics include
During and after my Master training in Biostatistics, I developed interst in the topics:
Coarsening

Complex data structures

Genetic epidemiology

Local influence

Missing data mechanisms and handling

Multicollinearity

Multiple testing

Multivariate dale model

Quality of life data

Statistical genetics



Overview 3rd cycle educational training - Orientation Life Sciences:


  • ICES Course bio-informatics.

Module 1: Ghent University 20 September, 3 October and 11 October 2001.

Module 2: Ghent University 26 September, 18 October and 25 October 2001.



  • Inference for mixed populations KULeuven 12-13 July 2001.

  • Course: Advances in population-based studies of complex genetic disorders, Erasmus Medical Centre Rotterdam (The Netherlands) 26-30 March 2001.

  • Course on “Handling Non-response”, Southampton (UK) 17-19 May 2000.

  • Course Medical Biology, Hasselt University, February 2000.

  • Course Survey Methodology, Hasselt University, January-February 2000.

  • SAS course on data step programming and macro writing (P. Meyvisch) EORTC 29 March - 1 April 1999.

  • Course: Multivariate Statistics in Practice, Groningen University (The Netherlands) 24-27 November 1997.

  • Course: computerintensieve methods in statistics (S+ environment) Hasselt University, 1997.


References :

Prof. Dr. Andreas Ziegler


Institut fuer Medizinische Biometrie und Statistik
Universitaet zu Luebeck
Ratzeburger Allee 160
23538 Luebeck
Fon: +49 (451) 500-2780
Fax: +49 (451) 500-2999
Web.imbs-luebeck.de
Prof Dr G Molenberghs

Center for Statistics


Hasselt University
Agoralaan - building D
B- 3590 Diepenbeek
E-mail: geert.molenberghs@uhasselt.be


  1. Know-how 5: Developing a culture of innovation

I was a co-founder and the scientific director of an SME (2006-2010) that offers service in statistics, in particular in the field of statistical genetics and genetic epidemiology. Since December 2007, this SME has been acknowledged as an official spin-off of the Ghent University. In 2008, StepGen became an official “collaborating centre” to the European EU funded network of Excellence GA2LEN.


Building upon the aforementioned expertise, lobbying activities have started in order to found a first-spinoff at ULg.



  1. Know-how 6: Statistical genetics


Research topics in statistical genetics include
Components analysis

FBAT testing

Gene-environment interactions

Gene-gene interactions and interaction graphs

Genetic heterogeneity

Genetic imprinting

Genome-wide association analysis

Kinship and genomic background

Multifactor dimensionality reduction strategies

Multi-locus or combined group approaches

Noisy or erroneous data handling

Omics integrated analysis

Phenocopies

Population stratification

Predictive disease models

Pre-screening algorithms and approaches

Simultaneous signficicance assessment

Winner’s curse



Overview 3rd cycle educational training - Orientation: Life Sciences


  • Workshop: Statistical analysis of genetic data in families, Leuven, Belgium, 11-15 August 2008.

  • FAMHAP, Bonn, Germany, 6-7 June 2008.

  • Good practice in DNA microarray analysis, Munich, Germany, 26-29 November 2007.

  • 37th International training workshop on the use of GelCompar II and Bionumerics, Sint-Martens-Latem, Belgium, 25-26 september 2006.

  • S.A.G.E. course: statistical analysis for genetic epidemiology; Department of Cardiovascular Diseases KUL, Belgium, 17-20 July 2006.

  • SAS JMP genetics course; Department of cardiovascular diseases KUL, Belgium, 21-22 July 2006.

  • Erasmus Summer Program at Erasmus Medical Centre Rotterdam (The Netherlands) 7-25 augustus 2006:

  • Genetic epidemiology of complex diseases (Cornelia Van Duijn – Erasmus MC Rotterdam, The Netherlands / Bertram Müller – Max Planck Institute Munich, Germany).

  • Introduction to genomics and bioinformatics (Cornelia Van Duijn – Erasmus MC Rotterdam, The Netherlands).

  • Searching genes of complex disorders (Ben Oostra – Erasmus MC Rotterdam, The Netherlands, André Uitterlinden – Erasmus MC Rotterdam, The Netherlands).

  • Course Bar Harbor, 9-15 October 2003 “Short course on mathematical approaches to the analysis of complex phenotypes” , with topics including:

  • Complex trait analysis (Gary Churchill, The Jackson Laboratory) / Introduction to QTL mapping in model organisms (Karl Broman, Johns Hopkins University).

  • A missing data perspective on QTL mapping (Saunek Sen, University of California, San Fransisco).

  • Introduction to human genetic linkage (Josee Dupuis, Genome Therapeutics Corporation).

  • Issues in contemporary human genetic analysis: haplotype maps, bioinformatics tools, and novel statistical tools (Nicholas Schork, Univerisity of California, San Diego).

  • Experimental design for cDNA microarrays (Gary Churchill, The Jackson Laboratory).

  • Gene expression with signature sequencing (Natalie Blades, The Jackson Laboratory).

  • ANOVA methods for microarray analysis (Gary Churchill, The Jackson Laboratory) / Analysis of microarray time course data (Christina Kendziorski, University of Wisconsin).

  • Bioinformatics resources for complex traits (Carol Bult, The Jackson Laboratory).


Reference:

Prof Dr N Laird

Department of Biostatistics

655 Huntington Avenue


Building II 4th Floor, Room 447
Boston, MA 02115
USA
e-mail: laird@hsph.harvard.edu
Prof Dr ST Weiss

http://www.channing.harvard.edu/weiss.htm


Department of Environmental Health
Channing Laboratory Room 461
181 Longwood
Boston, MA 02115
USA
e-mail: scott.weiss@channing.harvard.edu
Fundamental research at Harvard (2003-2005):
Harvard School of Public Health, department of Biostatistics, Boston MA, USA :
start : 05/05/2003

end: 31/05/2005

purpose : post-doctoral fellow researcher on statistical genetics
My job involved fundamental research. I was a member of several work groups to expand my know-how:


    • Computing Work Group

    • Environmental Statistics

    • Gene-environment Interactions

    • Psychiatric Biostatistics

    • Longitudinal Data Working Group

    • HIV Working Group

These topics still largely determine my current activities as an advisor or researcher. As an active researcher I mainly focus on genome-wide family-based association tests. The Channing Seminar Series (organizer: Channing Laboratories at Harvard Medical School) are invaluable to translate practical problems into research ideas.





  1. Know-how 7: Corporate thinking

At an international level I am establishing a network of young European researchers, with different backgrounds, to tackle problems related to gene-environment or gene-gene interactions large-scale screening, and to assess the impact of biological and genetic networks to disease development. It is my strong belief, and the belief of those in the virtual network, that these type of problems can only be dealt with when gears are shifted and when different viewpoints are merged.





  1. Know-how 8: Project management

During my stay in the US I took the Biotechnology Project Management course at the Harvard Extension School. Whether it is a large or a small project, good management is a determining factor for its success. The course focused on identifying and understanding responsibilities, activities and competences that are required for excellent project management in a biotech environment. Topics included: drug development, regulatory bodies, project life cycle, group structures and leadership, problem solving techniques, communication skills, project monitoring, project closure. During the course of my career I have had ample opportunity to bring theory into practice (for instance, GA2LEN, FP7-ICT-2009-6, FP7-HEALTH-2009-2.1.1-3).



Overview 3rd cycle educational training - Orientation: Management


  • FP7 competitive writing, KUL 2009

  • ERC grant applications, KUL 2009

  • EU preparatory course (http://www.e-t-i.be/eu_concours.asp) 2008

  • Biotechnology project management, spring term course jointly organized by the Harvard Extension School and the Massachusetts Biotechnology Council, 2005



Reference:

Prof Dr P Van Cauwenberge

Rector Ghent University

Sint-Pietersnieuwstraat 25

B-9000 Ghent

e-mail: Paul.VanCauwenberge@UGent.be



III.3. Activities related to professional knowledge acquisition (other than education)



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  • Know-how 2: Education and development
  • Thesis jury member (since 2008)
  • Thesis committee member (depuis 2008)
  • Diplôme dÉtudes Approfondies committee member (depuis 2007)
  • Promotor of doctoral students (since 2006)
  • Statistical consulent of doctoral students (since 2004)
  • Jury/committee member (since 2008)
  • (Co-)Promotor of master students
  • Know-how 3: Communication and knowledge dissemination
  • Know-how 4: Biostatistics
  • Know-how 5: Developing a culture of innovation
  • Know-how 6: Statistical genetics
  • Know-how 7: Corporate thinking
  • Know-how 8: Project management
  • III.3. Activities related to professional knowledge acquisition (other than education)

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