Conclusions in these domains are the result of pure reasoning, starting from a set of basic assumptions. My academic activities as a researcher in fundamental mathematics (from 1/9/1994 to 31/1/1998) mark a period of further development in logical and structural thinking.
Overview 3rd cycle educational training – Orientation Mathematics:
Short course: Genome-wide association studies (with co-teacher Andreas Ziegler – University of Luebeck/Germany) – Brazil (Dec 2010).
Short course: Gene-gene and gene-environment interactions – An overview of methods and available software, UMCG, Groningen – the Netherlands (8 May 2009)
Short course: Family-based designs in genetic association studies, UVic – Spain (30 June, 2008).
University teacher and responsible for courses in statistics (3rd Bachelor Dentistry; Medische Statistiek en Methodologie van Onderzoek, Ghent University, Ghent, Belgium (2006-2008).
University teacher and responsible for Statistical Genetics, Master of Statistical Data Analysis, Ghent University, Ghent, Belgium (2005-2006; 2007-2008).
University teacher and/or responsible for modules in statistics (2de Bachelor in Mathematics; “Kansrekenen en wiskundige statistiek”, Ghent University, Ghent, Belgium 2005-2008).
Short course: FBAT/PBAT course in Europe; Institute of Biology, Lille – France (March 30-31, 2005).
Short course: Using FBAT and PBAT to Analyze Family-Based Association Studies in Genetics; Harvard School of Public Health (HSPH) Boston – VS (January 24-26, 2005).
Short course: The Analysis of Family Based Association Studies in Genetics; Department of Medical Epidemiology and Biostatistics (MEB) Karolinksa Institutet, Stockholm - Sweden (March 24-26, 2004).
University teaching assignments for different modules in statistiek (Calculus for Statistics, Multivariate Techniques, Statistical Reading) Master of Applied Statistics Program Hasselt University, Diepenbeek, Belgium (1999-2002).
Assistant for the practical training sessions in “analyse, lineare algebra en analytische meetkunde”, Bachelor of Science Program, Ghent Univeristy, Ghent, Belgium (1993-1997).
Assistant of introductory summer courses for students in civil engineering, fysics, mathematics and informatics: “meetkunde en algebra”, Ghent University, Ghent, Belgium (1992-1996).
Realization of supervised self-study and development of didactical tools I have a shared responsibility in work package WP 1.1. of the Global Allergy and Asthma European Network GA2LEN with the Charité (Germany) in particular for the part on e-learning and e-testing. To create an extensive compendium of useful material I worked out new goals for the 4th work year of GA2LEN on e-learning and e-testing and created the basis for an Instructional Design template to be used for pre- and post-testing knowledge during future GA2LEN Allergy Schools.
A reflection of aforementioned activities is highlighted in the publication “Education via E-testing” in GA2LEN News – Spreading excellence in allergy and asthma, nr 10, devoted to “Creating excellence through education & training” (http://www.GA2LEN.net//files_new/filesPublic/Publication_GA2LEN%20News10.pdf).
Prof Dr J A Thas
Vakgroep Fundamentele en Computergerichte Wiskunde
Galglaan 2 B-9000 Ghent
Reference E-learning à GA2LEN:
Prof Dr T Zuberbier
Charité - Universitätsmedizin Berlin
Klinik für Dermatologie, Venerologie und Allergologie
D - 10117 Berlin
During my professional activities I have been giving both basic and specialized courses. Self-study became increasingly important. This explains my search for alternative educational tools that stimulate self-study, but simultaneously allow for fast detection of problems and accurate interaction.
Task force group to reorganize Probability / Statistics / Stochastics in the Bachelors of the Engineering curriculum (with L Wehenkel and V Denoël)
Work group to create a new “Masters in Epidemiology” at Antwerp University (responsible for programme item “Genetic epidemiology”). Start of group activities: 2010
Collaboration set up between the University of Maastricht (R Westra) and the University of Liège concerning giving guest-lectures within the corresponding existing bioinformatics programs. Practical start: academic year 2010-2011
Secretary of the Educational Board – Biomedical Civil Engineering (Ulg; 2008-2009, 2009-2010)
Member of AIM, Association des Ingénieurs de Montefiore (2008 -)
Learning from data project: coordination of practical implementation, Hasselt university in close collaboration with University of Maastricht (the Netherlands) 2002
Thesis supervision Doctorate Thesis jury member (since 2008)
Carolien Bettens (Antwerp University); Topic: The genetic architecture of Alzheimer disease: in search of risk factors (21 October 2010)
Hugues Aschard (INSERM, France; student of Florence Demenais); Topic: Analyses multi-marqueurs et multi-phénotypes dans les études génétiques des maladies multifactorielles – exemple de l’asthme dans l’étude EGEA (3 December 2009).
Michel Journée (Liège University); Topic: Geometric algorithms for component analysis with a view to gene expression data analysis (4 June 2009).
Erik Quaeghebeur (Ghent University, Belgium; student of Gert de Cooman); Topic: Learning from samples using coherent lower previsions — Leren uit monsters met coherente onderprevisies (23 Jan 2009).
Thesis committee member (depuis 2008)
Wambo LI (doctorat en sciences vétérinaires - promoteur Michel Georges) - membre de comité de thèse depuis 16 Nov 2010
Gaëlle Marenne (CNIO, Spain; student of Nuria Malats and Emmanuelle Génin) ; Titre provisoire: Identification and development of tools to perform association analysis using the joint information on CNVs & SNPs with an application on the data of the Spanish Bladder Cancer (SBC)/EPICURO Study
Olivier Stern (Liège University : Faculté des Sciences Appliquées) ; Titre provisoire : Intégration de données génomiques et protéomiques et de banques de connaissances biologiques pour la découverte de biomarqueurs et la biologie systémique
Vincent Botta (Liège University : Faculté des Sciences Appliquées) ; Titre provisoire : Apprentissage automatique appliqué à la génomique.
Diplôme d'Études Approfondies committee member (depuis 2007)
Zhiyang Zhang (GIGA, Liège University); Titre: Marker imputation with low-density marker panels in Holstein cattle (2009-2010)
Vincent Botta (Liège University : Faculté des Sciences Appliquées) ; Titre : Prédiction du risque génétique par apprentissage automatique supervisé dans le cadre des maladies complexes (2007-2008).
Promotor of doctoral students (since 2006)
François Van Lishout (Liège University); Titre provisoire : TBA – promotor (with L Wehenkel)
Jestinah Mahachie (Liège University); Titre provisoire : Des méthodes de screening des associations génétiques pour des données complexes et multidimensionelle - promotor
Lizzy De Lobel (Ghent University); Titre provisoire : Alternative methods to detect gene-gene interactions - promotor.
Peter Konings (Catholic University Leuven); Titre provisoire : Identification and analysis of CNVs in human genetics - copromotor.
Jeroen Huyghe (Antwerp University); Titre: Identification of genes contributing to human complex diseases and traits in the genetically isolated Saami and the general European population- copromotor. Thesis defended April 6, 2011.
Statistical consulent of doctoral students (since 2004)
Marie Joossens (Catholic University Leuven); Topic: Gut microbiota in relation to Crohn’s disease. Doctoral thesis defended in 2010.
Ingrid Arijs (Catholic University Leuven); Topic: micro-array analyses of Crohn patients prior to and after therapy. Doctoral thesis defended in 2010
Marieke Pierik (Catholic University Leuven); Topic: Susceptibility to inflammatory bowel diseases and pharmacogenetic predictors of treatment outcome in the Flemish population. Thesis defended in 2006.
Olga Bijnens (Hasselt University); Topic: Het gebruik van cycloongas en staalgrit bij de “in situ” immobilisatie van metaalgecontamineerde bodems: een statistische benadering. Thesis defended in 2006.
Master Jury/committee member (since 2008)
Jean-Yves Nicolas ; Topic : Identification de signatures multiples par ensemble d'arbres de décision. Thesis defended in 2010-2011
Arnaud Joly ; Topic : Amélioration des forêts aléatoires dans le cadre de problèmes à très haute dimension. Thesis defended in 2010-2011
Sébastien Roland; Topic: Prioritisation de gènes par ensembles d’arbres de decision. Thesis defended in 2009-2010
Aline Serteyn; Topic: Wearable ECG-monitor for real-time epileptic seizure detection. Thesis. defended in 2009-2010
Stéphane Wenric; Topic: Complétion du réseau OMIM par apprentissage automatique. Thesis defended in 2009-2010
François Ghilain; Topic: Algorithmes de réduction de données transcriptomiques temporelles. Thesis defended in 2008-2009
(Co-)Promotor of master students ULg TFE faculty of applied sciences (since 2008)
Thomas Leysen; Titre provisoire: Efficient genome-wide two-locus epistasis testing in disease association studies (on Erasmus Exchange from ULg to University of Vic. Promotor at host institution: Malu Calle). Thesis to be defended in 2010-2011
Jose Rial; Titre provisoire: Association testing in the presence of gene-gene interactions : MB-MDR compared to BOOST (on Erasmus Exchange from computer science at the University of A Coruña, in Spain, to ULg). Thesis to be defended in 2010-2011
Arnaud Blanjean; Titre provisoire : Random Jungle for statistical genetics. Thesis to be defended in 2010-2011
UHasselt Master of Science in Biostatistics
Dominik Grathwohl; Topic: A Model-Based 40 to 1 Algorithm in Microarray Analysis. Thesis defended in 2002.
Chris Muller; Topic: The EigenApples Approach. Thesis defended in 2002.
Mbah Alfred Kubong; Topic: Growth of Dutch PKU Patients. Thesis defended in 2002.
UHasselt Master of Science in Applied Statistics
He Liang; Topic: Dealing with Discreteness: Confidence Intervals for Difference in Proportions. Thesis defended in 2002.
Petra Goyens; Topic: Evolution and Effect of Trans Fatty Acids during Pregnancy. Thesis defended in 2002.
Valerie Poulart; Topic: Checking for proportional hazards assumption in survival studies. Thesis defended in 2002.
Maarten Borremans; Topic: The comparison of DNA sequences using a Mahalanobis-type distance measure: a sensitivity analysis? Thesis defended in 2001.
Nahson Sigalla; Topic: Sampling Schemes for Large Units (co-supervisor). Thesis defended in 2001.
Anthony Gichangi; Topic: Missing data in the health interview survey 1997. Thesis defended in 2000.
Know-how 3: Communication and knowledge dissemination
Dissemination of research and science
Via involvement in GA2LEN, in particular WP 1.1
Via research activities
Via involvement in BioScope-IT, a FlandersBio's Bioinformatics Service Project to reduce the gap between Flemish biotech companies to implement bioinformatics applications.
Press reports of scientific research, targeting a non-scientific audience
"In Utero Smoke Exposure and Impaired Response to Inhaled Corticosteroids in Children With Asrhma." (Ulg REFLEXIONS, February 2011)
“UGent lanceert nieuwe medische spin-off” (Trends, 17 April 2008).
“ ‘StepGen’ nieuwe spinoff van de UGent” (UGent Press Release / Technologie Transer, 9 April 2008).
“Statistical method provides unprecedented look at genetic underpinnings of complex diseases” – appeared in Harvard School of Public Health Press Releases, after an interview by Christina Roache of the HSPH press department with Dr C Lange and myself.
“Een massa gegevens” - appeared in Knack, Mens & Cultuur 3, nr 28-29, 13 - 26 July 2005. This publication was composed by D Draulans on the basis of a text proposed by myself.
Overview 3rd cycle educational training – Orientation Communication
Advocacy workshop on developing the basic skills of doing advocacy and lobbying work (Miriam Stein, lobbyist with Cooperative Metropolitan Ministries) Newton (USA) 16 May 2005.
Biotechnology project management, spring term course organised by the Harvard Extension School and the Massachusetts Biotechnology Council, 2005
Inter-university doctoral training: Wecom – orald and written scientific communication, Hasselt University, 2002.
Interculturele Communicatietraining, Hasselt University, 6-7 September 2001.
Institut fuer Medizinische Biometrie und Statistik
Universitaet zu Luebeck
Ratzeburger Allee 160
Fon: +49 (451) 500-2780
Fax: +49 (451) 500-2999
Prof Dr G Molenberghs
Center for Statistics
Agoralaan - building D
B- 3590 Diepenbeek
Know-how 5: Developing a culture of innovation
I was a co-founder and the scientific director of an SME (2006-2010) that offers service in statistics, in particular in the field of statistical genetics and genetic epidemiology. Since December 2007, this SME has been acknowledged as an official spin-off of the Ghent University. In 2008, StepGen became an official “collaborating centre” to the European EU funded network of Excellence GA2LEN.
Building upon the aforementioned expertise, lobbying activities have started in order to found a first-spinoff at ULg.
Know-how 6: Statistical genetics
Research topics in statistical genetics include Components analysis
Building II 4th Floor, Room 447
Boston, MA 02115
Prof Dr ST Weiss
Department of Environmental Health
Channing Laboratory Room 461
Boston, MA 02115
Fundamental research at Harvard (2003-2005): Harvard School of Public Health, department of Biostatistics, Boston MA, USA :
start : 05/05/2003
purpose : post-doctoral fellow researcher on statistical genetics
My job involved fundamental research. I was a member of several work groups to expand my know-how:
These topics still largely determine my current activities as an advisor or researcher. As an active researcher I mainly focus on genome-wide family-based association tests. The Channing Seminar Series (organizer: Channing Laboratories at Harvard Medical School) are invaluable to translate practical problems into research ideas.
Know-how 7: Corporate thinking
At an international level I am establishing a network of young European researchers, with different backgrounds, to tackle problems related to gene-environment or gene-gene interactions large-scale screening, and to assess the impact of biological and genetic networks to disease development. It is my strong belief, and the belief of those in the virtual network, that these type of problems can only be dealt with when gears are shifted and when different viewpoints are merged.
Know-how 8: Project management
During my stay in the US I took the Biotechnology Project Management course at the Harvard Extension School. Whether it is a large or a small project, good management is a determining factor for its success. The course focused on identifying and understanding responsibilities, activities and competences that are required for excellent project management in a biotech environment. Topics included: drug development, regulatory bodies, project life cycle, group structures and leadership, problem solving techniques, communication skills, project monitoring, project closure. During the course of my career I have had ample opportunity to bring theory into practice (for instance, GA2LEN, FP7-ICT-2009-6, FP7-HEALTH-2009-2.1.1-3).
Overview 3rd cycle educational training - Orientation: Management
FP7 competitive writing, KUL 2009
ERC grant applications, KUL 2009
EU preparatory course (http://www.e-t-i.be/eu_concours.asp) 2008
Biotechnology project management, spring term course jointly organized by the Harvard Extension School and the Massachusetts Biotechnology Council, 2005
Prof Dr P Van Cauwenberge
Rector Ghent University
III.3. Activities related to professional knowledge acquisition (other than education)