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Part I: Personalia First Name: Kristel Place of birth, Date: Dendermonde, 3 June 1969 Address

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Part I: Personalia First Name: Kristel Place of birth, Date: Dendermonde, 3 June 1969 Address



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  1. Self-study time


During study/research leaves


  • Harvard School of Public Health, Boston, USA (November 2009). Topic: Epistasis screening in genome-wide association studies.

  • Institut national de la santé et de la recherché médicale (INSERM / Florence Demenais) in Paris, France (July, November 2009). Topic: jointly testing of groups of markers; setting out a strategy for new project proposals.

  • Departament de Biologia de Sistemes, Universitat de Vic, Barcelona, Spain (December 2008 – January 2009, February 2010). Topic: Incorporating machine learning techniques in the search for epistatic effects.

  • Harvard School of Public Health, Boston, USA (October 2008). Topic: Using phenotypes in family members in genetic association testing.

  • Departament de Biologia de Sistemes, Universitat de Vic, Barcelona, Spain (May – June 2008). Topic: Genetic interactions – methodological developments for large-scale screening.

  • Municipal Institute of Medical Research (IMIM) Barcelona, Spain, 2007 (invited by Dr M Kogevinas). Topic: Missing SNPs in candidate genes.

  • Municipal Institute of Medical Research (IMIM) Barcelona, Spain, 2006 (invited by Dr M Kogevinas). Topic: non-parametric techniques to detect epistasis in ECRHS II data set.

  • Department of biostatistics, HSPH, Boston, USA, 2005 (invited by Dr N Laird). Topic: Optimalization of FBAT screening methodology

  • Department of biostatistics, HSPH, Boston, USA, 2002 (invited by Dr N Laird). Topic: Research on the use of the Dale model in genetic association studies.



  1. Publications (including those for doctorate or study)




Articles in internationally reviewed journals
Published /accepted articles or letters


  • Arijs I, Van Steen K, Quintens R, Lemaire K, Van Lommel L, De Hertogh G, Van Assche G, Vermeire S, Geboes K, Schuit F, Rutgeerts P (2011) Mucosal gene expression of cell adhesion molecules, chemokines and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment. Am J Gastroenterol 106: 748–761.

  • Breynaert C, Ferrante M, Fidder M, Van Steen K, Noman M, Ballet V, Vermeire S, Rutgeerts P, Van Assche G (2011) Tolerability of shortened infliximab infusion times in patients with inflammatory bowel diseases: a single center cohort study. Am J Gastroenterol 106:778–785.

  • Cattaert T, Calle ML, Dudek SM, Mahachie John JM, Van Lishout F, Urrea V, Ritchie MD, Van Steen K (2011) A detailed view on Model-Based Multifactor Dimensionality Reduction for detecting gene-gene interactions in case-control data in the absence and presence of noise . (invited paper of K Van Steen as expert entry to special issue on epistasis). Ann Hum Genet. 2011 Jan;75(1):78-89

  • Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, De Ruyck N, Blomme K, Sousa AR, Marshall RP, Bachert C. (2011) Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol. 2011 Nov;128(5):989-995.e8. Epub 2011 Sep 28.

  • Jürgens M, Mahachie John JM, Cleynen I, Schnitzler F, Fidder H, Ballet V, Noman M, Hoffman I, Van Assche G, Rutgeerts PJ, Van Steen K, Vermeire S (2011) Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn's Disease. Clinical Gastroenterology and Hepatology 9(5): 421-427.

  • Joossens M, Huys G, Van Steen K, Cnockaert M, Vermeire S, Rutgeerts P, Verbeke K, Vandamme P, De Preter V (2011) High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples. FEMS Microbiol Ecol. 2011 Feb;75(2):343.

  • Mahachie John JM, Cattaert T, Van Lishout F, Van Steen K (2011) Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data. European Journal of Human Genetics 19, 696-703.

  • Mahachie John JM, Cattaert T, De Lobel L, Van Lishout F, Empain A, Van Steen K (2011) Comparison of genetic association strategies in the presence of rare alleles – accepted to BMC Genetics

  • Márquez L, Shen C, Cleynen I, De Hertogh G, Van Steen K, Machiels K, Perrier C, Ballet V, Organe S, Ferrante M, Henckaerts L, Rutgeerts P, Ceuppens J, Vermeire S (2011) Effects of Haptoglobin polymorphisms in susceptibility to Inflammatory Bowel Disease and in triggering murine colitis. Gut doi:10.1136/gut.2011.240978

  • Moens LN, De Rijk P, Reumers J, Van den Bossche MJ, Glassee W, De Zutter S, Lenaerts AS, Nordin A, Nilsson LG, Medina Castello I, Norrback KF, Goossens D, Van Steen K, Adolfsson R, Del-Favero J. (2011) Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population. PLoS ONE 6(8): e23450. doi:10.1371/journal.pone.0023450

  • Op De Beéck K, Maes L, Van den Bergh K, Derua R, Waelkens E, Van Steen K, Vermeersch P, Westhovens R, De Vlam K, Verschueren P, Hooijkaas H, Blockmans D, Bossuyt X. (2011) Heterogeneous nuclear ribonucleoproteins as targets of autoantibodies in systemic rheumatic diseases. Arthritis Rheum. Sep 8. doi: 10.1002/art.33327. [Epub ahead of print]

  • Schnitzler F, Fidder H, Ferrante M, Ballet V, Noman M, Van Assche G, Spitz B, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P (2011) Outcome of pregnancy in women with inflammatory bowel disease treated with infliximab. Inflamm Bowel Dis. 2011 Jan 6. [Epub ahead of print]

  • Van Steen K (2011) Travelling the world of gene-gene interactions – invited submission to Briefings in Bioinformatics (invited paper). Brief Bioinform doi: 10.1093/bib/bbr012

  • Van Steen K and Sleegers K (2011) A report of the 1st biennial meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010. Annals of Human Genetics 75(4): 554-557.

  • Van Steen K (2011) Perspectives on Large-Scale Multi-Stage Family-Based Association Studies (invited paper) Statistics in Medicine DOI: 10.1002/sim.4259.

  • Ziegler A, Van Steen K, Wellek S (2011) Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis. Breast Cancer Res Treat 128(1):197-201.




  • Arijs I, Quintens R, Van Lommel L, Van Steen K, De Hertogh G, Lemaire K, Schraenen A, Perrier C, Van Assche G, Vermeire S, Geboes K, Schuit F, Rutgeerts P (2010) The predictive value of epithelial gene expression profiles for response to infliximab in Crohn’s disease. Inflamm Bowel Dis. 2010 Dec;16(12):2090-8. doi: 10.1002/ibd.21301.

  • Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K (2010) Presence of IL-5 and IgE-antibodies to Staphylococcus aureus enterotoxins in nasal polyps is associated with co-morbid asthma. J Allergy Clin Immunol. 2010 Nov;126(5):962-8, 968.e1-6.

  • Calle ML, Urrea V, Van Steen K (2010) mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits. Bioinformatics Applications Note 26 (17): 2198-2199

  • Cattaert T, Urrea V, Naj AC, De Lobel L, De Wit V , Fu M, Mahachie John JM, Shen H, Calle ML, Ritchie MD, Edwards T, Van Steen K. (2010) FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals, PLoS One 5 (4).

  • Cleynen I, Mahachie John J. M, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K and Vermeire S (2010) Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE 5(9): e12952. doi:10.1371/journal.pone.0012952

  • Cohen R, Raby B, Van Steen K, Fuhlbrigge A, Celedon J, Rosner B, Strunk R, Zeiger R, and Weiss S (2010) In utero smoke exposure and impair response to inhaled corticosteroids in children with asthma. Journal of allergy and clinical immunology 126(3), 491-497

  • De Lobel L, Geurts P, Baele G, Castro-Giner F, Kogevinas M, Van Steen K (2010) A screening methodology based on Random forests to improve the detection of gene-gene interactions. European Journal of Human Genetics 18, 1127–1132

  • Joossens M, Van Steen K, Branche J, Sendid B, Rutgeerts P, Vasseur F, Poulain D, Broly F, Colombel J, Vermeire S and Chamaillard M. (2010) Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohns disease. Inflamm Bowel Dis 16 (1): 58-67.

  • Fidder H, Van Steen K, van Assche G, Rutgeerts P and Vermeire S (2010) Immortal time bias and infliximab-related mortality and malignancy incidence. (letter to the editor). Gut 59: 416.

  • Fidder H, Van Steen K, van Assche G, Rutgeerts P and Vermeire S (2010) Reanalysis of death risk in long-term follow-up in infliximab patients versus controls (letter to the editor). Gut 59: 416.

  • Henckaerts L, Cleynen I, Brinar M, Mahachie John JM, Van Steen K, Rutgeerts P, Vermeire S (2010) Genetic variation in the autophagy gene ULK1 and risk for Crohn’s disease. Inflamm Bowel Dis. 2010 Nov 28. [Epub ahead of print]

  • Mahachie John JM, Baurecht H, Rodriguez E, Naumann A, Wagepfeil S, Memper M, Klopp N, Novak N, Bieber T, Wichmann H-E, Illig T, Van Steen K, Weidinger S (2010) Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. Allergy 65 (7): 875-882.

  • Vermeulen N, Vermeire S, Van Steen K, Arijs I, Michiels G, Ballet V, Schuit F, Van Lommel L, Rutgeerts P, Bossuyt X (2010) Identification of novel antibodies in inflammatory bowel disease by protein microarray. Inflamm Bowel Dis 2011;17:1291–1.




  • Arijs I, Hertogh G. D, Lemaire K, Quintens R, Lommel L. V, Van Steen K, Leemans P, Cleynen I, Assche G. V, Vermeire S, Geboes K, Schuit F, Rutgeerts P. (2009) Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One 4 (11) : 7984.

  • Arijs I, Li K, Toedter G, Quintens R, Lommel L. V, Van Steen K. , Leemans P, Hertogh G. D, Lemaire K, Ferrante M, Schnitzler F, Thorrez L, Ma K, Song X. R, Marano C, Assche G. V, Vermeire S, Geboes K, Schuit F, Baribaud F, Rutgeerts P. (2009) Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis. Gut 58 (12): 1612-1619.

  • Bogaert V, Vanbillemont G, Taes Y, De Bacquer D, Deschepper E, Van Steen K, and Kaufman J. (2009) Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men. Eur J Endocrinol 161 (1): 171-177.

  • Henckaerts L, Van Steen K, Verstreken I, Cleynen I, Franke A, Schreiber S, Rutgeerts P and Vermeire S. (2009) Genetic risk profiling and prediction of disease course in Crohns disease patients. Clin Gastroenterol Hepatol 7 (9): 972-980.e2.

  • Henckaerts L, Nielsen K. R, Steffensen R, Van Steen K, Mathieu C, Giulietti A, Wouters P. J, Milants I, Vanhorebeek I, Langouche L, Vermeire S, Rutgeerts P, Thiel S, Wilmer A, Hansen T. K, den Berghe G. V. (2009) Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 37 (1): 192-201 e1-3.

  • Raby B, Van Steen K, Lasky-Su J, Tantisira K, Kaplan F, Weiss ST (2009). Importin-13 DNA sequence variants are associated with improved airway hyperresponsiveness in childhood asthma. Respiratory Research 10: 67

  • Ripatti S, Becker T, Bickeböller H, Dominicus A, Fischer C, Humphreys K, Jonasdottir G, Moreau Y, Nilsson S, Olsson M, Ploner A, Sheehan N, Van Steen K, Wessman J, Baur M, van Duijn C, Palmgren J (2009). GENESTAT: an information portal for design and analysis of genetic association studies.. Eur J Hum Genet. 17 (4): 533-536.

  • Schnitzler F, Fidder H, Ferrante M, Noman M, Arijs I, Van Assche G, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P. (2009) Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn’s disease. Inflamm Bowel Dis 15 (9): 1295-1301.

  • Schnitzler F, Fidder H, Ferrante M, Noman M, Arijs I, Van Assche G, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P. (2009) Long-term outcome of treatment with infliximab in 614 patients with Crohns disease: results from a single-centre cohort. Gut 58 (4): 492-500.

  • Vanbillemont G, Bogaert V, De Bacquer D, Lapauw B, Goemare S, Toye K, Van Steen K, Taes Y, Kaufman JM (2009) Polymorphisms of the sex hormone-binding globulin gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men. Clin Endocrinol. 70 (2): 303-310.




  • Bogaert V, Taes Y, Konings P, Van Steen K, Bacquer D. D, Goemaere S, Zmierczak H, Crabbe P, Kaufman J. (2008) Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings. Clin Endocrinol (Oxf) 69 (1): 129-135.

  • Calle M, Urrea V, Malats N, Van Steen K. (2008) Improving strategies for detecting genetic patterns of disease susceptibility in association studies – Statistics in Medicine 27 (30): 6532-6546.

  • Castro-Giner F, Kogevinas M, Machler M, de Cid R, Van Steen K, Imboden M, Schindler C, Berger W, Gonzalez JR, Franklin KA, Janson C, Jarvis D, Omenaas I, Burney R, Rochat T, Estivill X, Anto JM, Wjst M, Probst-Hensch NM (2008) TNFA-3086 > A in two international population-based cohorts and risk of asthma. European Respiratory Journal 32 (2): 350-361.

  • Ferrante M, Vermeire S, Fidder H, Schnitzler F, Noman M, Van Assche G, De Hertogh G, Hoffman I, D’Hoore A, Van Steen K, Geboes K, Penninckx F, Rutgeerts P (2008). Long-term outcome after infliximab for refractory ulcerative colitis. Journal of Crohn’s and Colitis 2 (3): 219-225.




  • Ferrante M, Henckaerts L, Joossens M, Pierik M, Joossens S, Dotan N, Norman G, Altstock R, Van Steen K, Rutgeerts P, Van Assche G and Vermeire S. (2007) New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 56 (10): 1394-1403. Epub 2007 Apr 24.

  • Van Steen K, Laird NM, Markel P, Molenberghs G (2007) Approaches to handling incomplete data in family-based association testing. Ann Hum Genet. Mar 71 (Pt 2): 141-51. Epub 2006 Nov 10.



  • Efficace F, Bottomley A, Coens C, Van Steen K, Conroy T, Schoffski P, Schmoll H, Van Cutsem E, Köhne C-H (2006) Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer, Eur J Cancer. 42 (1): 42-49.

  • Pierik M, Joossens S, Van Steen K, Van Schuerbeek N, Vlietinck R, Rutgeerts P and Vermeire S (2006) Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis. 12 (1): 1-8.

  • Raby BA, Hwang E-S, Van Steen K, Tantisira K, Peng S, Litonjua A, Lazarus R, Gaillourakis C, Rioux J, Sparrow D, Silverman EK, Glimcher L, Weiss ST (2006) T-bet polymorphisms are associated with asthma and airways hyperresponsiveness, Am J Respir Crit Care Med 173 (1): 64-70.

  • Raby BA, Van Steen K, Lazarus R, Celedón JC, Silverman E, Weiss ST (2006) Eotaxin polymorphisms and serum total IgE levels in children with asthma, J Allergy Clin Immunol 117 (2): 298-305.




  • Mcqueen MB, Devlin B, Faraone SP, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly M, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo S-H, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mcinnis MG, Mcmahon F, Murphy DL, Nöthen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP and Laird NM (2005) Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence for susceptibility loci on chromosomes 6q and 8q, Am J Hum Genet. 77 (4): 582-595.

  • Murphy A, Mcqueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K (2005) Genomic Screening in Family Based Association Testing. Genet. Epidemiol. 29 (Suppl. 1): 91-95

  • Moerkerke B, Goetghebeur E, Van Steen K, Van Belle S, Cocquyt V (2005) Permutation based methods for analyzing quality of life data, Stat Med. 24 (24): 4055-4066.

  • Raby BA, Van Steen K, Celedon JC, Litonjua AA, Lange C, Weiss ST for the CAMP Research Group (2005) Paternal history of asthma and airway responsiveness in children with asthma, Am J Respir Crit Care Med. 172 (5): 552-558.

  • Van Ranst M, Joossens M, Joossens S, Van Steen K, Pierik M, Vermeire S, Rutgeerts P (2005) Crohn’s disease and month of birth. Inflammatory bowel diseases 11 (6): 597-599.

  • Van Steen K, Lange C (2005) PBAT: a comprehensive software package for genome-wide association analysis of complex family­based studies (Invited submission) Journal of Human Genomics 2 (1): 67-69.

  • Van Steen K, Mcqueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman Ek, Laird NM, Weiss St, Lange C (2005) Genomic screening and replication using the same data set in family-based association testing, Nature Genetics 37 (7): 683 – 691.

  • Van Steen K, Raby B, Molenberghs G, Thijs H, De Wit M, Peeters M (2005) An equivalence test for comparing DNA sequences, Pharmaceutical Statistics 4 (3): 203-214.




  • Efficace F, Biganzoli L, Piccart M, Coens C, Van Steen K, Cufer T, Coleman Re, Calvert Ha, Gamucci T, Twelves C, Fargeot P, Bottomley A (2004) Baseline health-related quality of life data as prognostic factors in a phase III multicenter study of women with metastatic breast cancer, Eur J Cancer 40 (7): 1021 – 1030.

  • Efficace F, Therasse P, Piccart M, Coens C, Van Steen K, Welnicka-Jaskiewicz M, Cufer T, Dyczka J, Lichinitser M, Shepherd L, De Haes JC, Sprangers MA, Bottomley A (2004) Health-related quality of life parameters as prognostic factors in a non-metastatic breast cancer population. An international multicenter study, Journal of Clinical Oncology 22 (16): 3381-3388.

  • Esters N, Pierik M, Van Steen K, Vermeire S, Claessens G, Joossens S, Vlietinck R, Rutgeerts P (2004) Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease, Am J Gastroenterol 99 (2): 299-305.

  • Franchimont D, Vermeire S, EL Housni H, Pierik M, Van Steen K, Gustot T, Quertinmont E, Abramowicz M, Van Gossum A, Deviere J, Rutgeerts P (2004) Deficient Host bacteria Interactions in Inflammatory Bowel Disease: the Toll - like Receptor (TLR)-4 Asp299Gly Polymorphism is Associated with Crohn’s Disease and Ulcerative Coliti, Gut 53 (7): 987-992

  • Joossens S, Daperno M, Shums Z, Van Steen K, Goeken J, Trapani C, Norman G, Godefridis G, Claessens G, Pera A, Pierik M, Vermeire S, Rutgeerts P and Bossuyt X (2004) Inter-assay and inter-observer variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis, Clin Chem 50 (8): 1422-1425.

  • Joossens S, Vermeire S, Van Steen K, Godefridis L, Claessens G, Pierik M, Vlietinck R, Aerts R, Rutgeerts P and Bossuyt X (2004) Pancreatic autoantibodies in inflammatory bowel disease, Inflammatory Bowel Disease 10 (6): 771-777.

  • Lange C, Van Steen K, Andrew T, Lyon H, Demeo DL, Raby B, Murphy A, Silverman EK, Macgregor A, Weiss ST, Laird NM (2004) A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects, Statistical Applications in Genetics and Molecular Biology 3 (1): Article 17.

  • Murphy A, Van Steen K, Lange C (2004) On missing phenotype data in multivariate family based association tests: FBAT-GEE-IMP and imputation strategies based on the EM-algorithm, the DA-algorithm and the conditional mean model, Far East J. Theo. Stat. 13 (2): 175-188.

  • Pierik M, Vermeire S, Van Steen K, Joossens S, Claessens G, Vlietinck R, Rutgeerts P (2004) Tumour necrosis factor- receptor 1 and 2 polymorhpisms in inflammatory bowel disease and their association with response to infliximab. Alimentary Pharmacology & Therapeutics 20: 303-310.

  • Van Steen K, Tahri N, Molenberghs G (2004) Introducing the multivariate Dale model in population based genetic association studies, Biometrical Journal = Biometrisches Zeitschrift 46 (2): 187-202.

  • Vermeire S, Rutgeerts P, Van Steen K, Joossens S, Claessens G, Pierik M, Peeters M, Vlietinck R (2004) Genome-wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity and epistasis, Gut 53 (7): 980-986.




  • Bottomley A, Thomas R, Van Steen K, Flechtner H, De Graeff A (2003) Guidelines for the use of epoetin: have quality-of-life benefits been proven, J Clin Oncol 21 (11): 2223; author reply 2224-2225

  • Jansen I, Molenberghs G, Aerts M, Thijs H, Van Steen K (2003) A Local Influence Approach applied to Binary Data from a Psychiatric Study, Biometrics, 59 (2): 410-419.

  • Joossens S, Van Steen K, Vermeire SV, Reinisch W, Colombel JF, Rutgeerts P (2003) Reply to: The value of serologic markers in indeterminate colitis: A prospective follow-up study. Gastroenterology 125 (3): 999-1000.

  • Vermeire S, Noman M, Van Assche G, Baert F, Van Steen K, Esters N, Joossens S, Bossuyt X, Rutgeerts P (2003) Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn’s disease: a prospective cohort study, Gastroenterology 125 (1): 32-39.




  • Bottomley A, Thomas R, Van Steen K, Fletchner H, Dzulbegovic B (2002) Erythropoietin improves quality of life – a response, Lancet Oncol 3 (9): 527.

  • Joossens S, Reinisch W, Vermeire S, Sendid B, Van Steen K, Poulain D, Peeters M, Geboes K, Bossuyt X, Vandewalle P, Oberhuber G, Vogelsang H, Rutgeerts P, Colombel JF (2002) The Value of Serologic Markers in Indeterminate Colitis: A Prospective Follow-up Study, Gastroenterology 122 (5): 1242-1247.

  • Bottomley A, Thomas R, Van Steen K, Fletchner H, Dzulbegovic B (2002) Human recombinant erythropoietin and quality of life: a wonder drug or something to wonder about, The lancet Oncology, 3 (3): 145-153.

  • Van Steen K, Curran D, Kramer J, Molenberghs G, Van Vreckem A, Bottomley A, Sylvester R (2002) Multicollinearity in Prognostic Factor Analyses using the EORTC QLQ-C30: Identification and Impact on Model Selection, Statistics in Medicine 21 (24): 3865-3884.




  • Van Steen K, Curran D, Molenberghs G (2001) Sensitivity Analysis of Longitudinal Binary Quality of Life Data With Dropout: An example using the EORTC QLQ-C30, Statistics in Medicine 20 (24): 3901-3920.

  • Van Steen K, Molenberghs G, Verbeke G, Thijs H (2001) A Local Influence Approach to Sensitivity Analysis of Incomplete Longitudinal Ordinal Data, Statistical Modelling: An International Journal, 1: 125-142.




  • Van Maldeghem H, Van Steen K (1999) Characterizations by Automorphism Groups of Some Rank 3 Buildings IV. Hyperbolic p-adic Moufang Buildings of Rank 3, Geometriae Dedicata 75 (2): 115-122.

  • Van Maldeghem H, Van Steen K (1999) Characterizations by Automorphism Groups of Some Rank 3 Buildings II. A Half Strongly-Transitive Locally Finite Triangle Building is a Bruhat-Tits Builing, Geometriae Dedicata 74 (2): 113-133.

  • Van Steen K (1999) Characterizations by Automorphism Groups of Some Rank 3 Buildings III. Moufang-Like Conditions, Geometriae Dedicata 74 (3): 225-240.




  • Van Maldeghem H, Van Steen K (1998) Characterizations by Automorphism Groups of Some Rank 3 Buildings I. Some Properties of Half Strongly-Transitive Triangle Buildings, Geometriae Dedicata 73 (2): 119-142.




  • Van Maldeghem H, Van Steen K (1997) Moufang Affine Buildings have Moufang Spherical Building at Infinity, Glasgow Math. J. 39 (3): 237-241.



Other articles
Under revision or submission


  • Alaerts M, Ceulemans S, Forero D, Moens LN, De Zutter S, Heyrman L, Lenaerts A-S, Norrback K-F, Goossens D, De Rijk P, Van Steen K, Adolfsson R, Del-Favero J. Genome scan in large complex pedigrees from an isolated Northern Swedish population – revision submitted

  • Arijs I, Quintens R, Lemaire K, Van Lommel L, Van Steen K, De Hertogh G, Van Assche G, Vermeire S, Geboes K, Schuit F, Rutgeerts P. The impact of infliximab therapy on the intestinal mucosal expression of genes involved in tissue remodelling in patients with inflammatory bowel disease – submitted

  • Bachert C, Cattaert T, Holtappels G, Howarth P, Kowalski M, Buhl R, Taube C, Korn S, Zhang N, Van Steen K, Bousquet J. Severe asthma is associated with Staphylococcus aureus enterotoxin specific IgE in two independent cohorts – submission-ready

  • De Lobel L, De Meyer H, Thijs L, Kouznetsova T, Staessen J, Van Steen K (2010) A Family-Based Association Test to Detect Gene-Gene Interactions in the Presence of Linkage – submission-ready

  • Gevaert Philippe, Van Bruaene Nicholas, De Ruyck Natalie, Blomme Katrien, Cattaert Tom, Sousa AnaR, Marshall Richard P, Van Steen K, Bachert Claus (2010) Mepolizumab, a humanised anti-IL-5 monoclonal antibody, as treatment of severe nasal polyposis – submission-ready

  • Haerynck F, Van Steen K, Cattaert T, Van daele S, Schelstraete P, Loeys B, De Baets F. Associatin of FCN1 and FCN2 gene polymorphisms with earlier onset of chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients – submission-ready

  • Lødrup Carlsen KC, Roll S, Carlsen KH, Mowinckel P, Wijga AH, Brunekreef B, Torrent M, Roberts G, Arshad SH, Kull I, Krämer U, von Berg A, Eller E, Høst A, Kuehni C, Spycher B, Sunyer J, Chen CM, Reich A, Arsanoj A, Puig C, Herbarth O, Van Steen K, Willich SN, Wahn U, Lau S, Keil T, for the working group of GA²LEN WP 1.5 ‘Birth Cohorts’(2010) Pets in infancy - asthma or allergy in school age? Meta-analyses with individual raw data from 11 European birth cohorts – in revision.

  • Mahachie John JM, Gusareva E, Van Lishout F, Cattaert T, Van Steen K. Lower-order effects adjustment in quantitative traits Mode-Based Multifactor Dimensionality Reduction – submission-ready

  • Mahachie John JM, Roll S, Lau S, Lødrup Carlsen KC, Carlsen KH, Kuehni C, Spycher B, Torrent M, Sunyer J, Chen CM , Heinrich J, Arshad SH, Roberts G, Gehring U, Kerkhof M, Wickman M, Kull I, Eller E, Bindslev-Jensen C, Kramer U, von Berg A, Wahn U, Van Steen K, Keil T. Longitudinal study of European birth cohorts on pet ownership up to age 10 years as a risk for childhood asthma - a GA²LEN project – submission-ready

  • Moens L, De Rijk P, Reumers J, Alaerts M, Ceulemans S, Forero D, Glassee W, De Zutter S, Heyrman L, Lenaerts A-S, Norrback K-F, Castello IM, Goossens D, Van Steen K, Adolfsson R, Del-Favero J (2010) Next generation sequencing and mutation analysis of the DISC1 pathway in schizophrenia – in revision.

  • Van Lishout F, Cattaert T, Mahachie John JM, Gusareva E, Théâtre E, Charloteaux B, Kvasz A, Cleynen I, Urrea V, Calle ML, Wehenkel L, Van Steen K. Efficient Implementation Of Model-Based Multifactor Dimensionality Reduction Enabling Large-Scale Association Analysis – submission-ready



Under construction


  • Arijs I, Van Lommel L, Van Steen K, De Hertogh G, Schuit F, Geboes K, Van Assche G, Vermeire S, Rutgeerts P. (2010). Gene expression profiling to predict the response of infliximab in patients with UC – under construction.

  • Calle M, et al, Van Steen K (2010) Multilocus information measures as pre-screening tool for multifactor dimensionality reduction in the context of epistasis – under construction.

  • Cleynen et al … Van Steen K …(2010) Detailed genetic characterization of interleukin 23 receptor shows epistatic effects of IL23R variants in Crohn's disease – under construction

  • De Greef E, Hoffman I, Smets F, Van Biervliet S, Scaillon M, Hauser B, Paquot I, Alliet P, Arts W, Dewit O, Peeters H, Baert F, D’Haens G, Rahier J F, Etienne I, Bauraind O, Van Gossum A, Vermeire S, Fontaine F, Muls V, Louis E, Van de Mierop F, Coche JC, Mahachie John JM, Van Steen K and Veereman G for the IBD working group of the Belgian Society of Pediatric Gastroenterology, Hepatology and Nutrition (BeSPGHAN) and the Belgian IBD Research and Development (BIRD) (2010) Profile of belgian pediatric crohn disease (cd) patients: presentation and diagnostic features – under construction

  • De Greef E, Hoffman I, Smets F, Van Biervliet S, Scaillon M, Hauser B, Paquot I, Alliet P, Arts W, Dewit O, Peeters H, Baert F, D’Haens G, Rahier J F, Etienne I, Bauraind O, Van Gossum A, Vermeire S, Fontaine F, Muls V, Louis E, Van de Mierop F, Coche JC, Mahachie John JM, Van Steen K and Veereman G for the IBD working group of the Belgian Society of Pediatric Gastroenterology, Hepatology and Nutrition (BeSPGHAN) and the Belgian IBD Research and Development (BIRD) (2010) Profile of belgian pediatric crohn’s disease (cd) patients: associations between variables at diagnosis – under construction

  • De Maeseneer D, Cocquyt V et al … Cattaert T, Van Steen K …(2010) Quality of life and body image after breast cancer surgery: a multicenter cross-sectional study comparing breast conserving surgery, mastectomy with and without reconstruction – under construction

  • Demenais F, Van Steen K (*) (2010) Review paper on multi-marker analysis – under construction (*): equally contributing with first author).

  • Joossens S, Colombel J-F, Vermeire S, Landers C, Van Steen K, Sendid B, Poulain D, Geboes K, Bossuyt X, Vandewalle P, Oberhuber G, Vogelsang H, Targan S, Rutgeerts P, Reinisch W. (2010) Anti-outer membrane of porine c and anti-12 antibodies in indeterminate colitis – under construction.

  • Joossens S, Halfvarson J, Romberg-Camps M, Van Steen K, Vermeire S, Jarnerot G, Stockbrugger R, Matthijs G, Vlietinck R, Bossuyt X, JF Colombel, Rutgeerts P, Tysk C. (2010) Seriological markers in twins with inflammatory bowel disease – under construction.

  • Rzehak P et al for the working group of GA2LEN-WP 1.5 ‘Birth Cohorts (2010) Body-mass-index trajectory classes and asthma onset in childhood. Results from European Birth Cohorts – a Global Allergy and Asthma European Network initiative – under construction.

  • Van Steen K, Vermeiren V, Huyghe J, Van de Peer Y (2010) GERONIMO and integrating omics data into MB-MDR screening for epistasis – under construction


Selection of 5 most representative publications


  • Cattaert T, Urrea V, Naj AC, De Lobel L, De Wit V , Fu M, Mahachie John JM, Shen H, Calle ML, Ritchie MD, Edwards T, Van Steen K (2010) FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. PLoS One, 5 (4).




  • Ripatti S, Becker T, Bickeböller H, Dominicus A, Fischer C, Humphreys K, Jonasdottir G, Moreau Y, Nilsson S, Olsson M, Ploner A, Sheehan N, Van Steen K, Wessman J, Baur M, van Duijn C, Palmgren J (2009). GENESTAT: an information portal for design and analysis of genetic association studies. European Journal of Human Genetics 17(4): 533-536 .




  • Van Steen K, Mcqueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman Ek, Laird NM, Weiss St, Lange C (2005) Genomic screening and replication using the same data set in family-based association testing. Nature Genetics 37 (7): 683-691.




  • Van Steen K, Laird NM, Markel P, Molenberghs G (2006), Approaches to handle incomplete data in family-based association testing. Annals of Human Genetics 71: 141-151.




  • Van Steen K, Tahri N, Molenberghs G (2004) Introducing the multivariate Dale model in population based genetic association studies. Biometrical Journal 46 (2): 187-202.



Internal reports


  • Calle, M. L., Urrea, V., Vellalta, G., Malats, N. & Van Steen, K. (2008) Model-Based Multifactor Dimensionality Reduction for detecting interactions in high-dimensional genomic data. Technical Report No. 24, Department of Systems Biology, Universitat de Vic, http://www.recercat.net/handle/2072/5001

  • Van Steen K, Laird NM (2004) Family based association tests and the FBAT toolkit. User’s Manual.

  • Van Steen K, Curran D (1999) Scoring SAS macros (in the context of Quality of Life data) included in the EORTC QLQC-30 Scoring Manual,EORTC study group on quality of life, Brussels.

  • Van Steen K, Carthy S, Curran D (1999) Analysis of Quality of Life: statistical guidelines manual (for EORTC internal use).

Books

Author


  • In December 2010 I was approached by Chapman & Hall/CRC (Taylor and Francis Group) to write a book (jointly with Andreas Ziegler) on “next generation sequence analysis “. Anticipated start of the writing: end of 2013.

  • In May 2007 I was approached by Springer – Editorial Statistics to write a book in the field of statistical genetics. I have accepted, in collaboration with my co-author Dr Aaron Isaacs (Erasmus Medical Centre, Rotterdam – the Netherlands). A first draft of a table has been accepted by the editors and sent out to the reviewers. Targeted publication: 2013.




    • Van Steen K and Iaacs A (20--) A Road Map to Genetic Association Studies: A user-oriented approach.



Articles in or part of books

Author / co-author





  • Van Steen K, Molenberghs G, Multicollinearity, 3rd edition encycl of biopharmac statistics - p836-p843 / Shein-Chung Chow [edit.], (2010), - http://www.amazon.com/Encyclopedia-Biopharmaceutical-Statistics-Third-SHEIN/dp/143982245X/ Invited revision of the 2004 publication below.




  • Molenberghs G, Beunkens C, Thijs H, Jansen I, Verbeke G, Kenward MG and Van Steen K, Analysis of incomplete data. In SAS System for Clinical Trials II. Dmitrienko A, Chuang-Stein C and D’Agostino R (Eds.) (2007) Cary: SAS Press, pp. 313-360.




  • Molenberghs G, Beunkens C, Jansen I, Thijs H, Van Steen K, Verbeke G, Kenward MG, Analysis of incomplete data. In 'Pharmaceutical Statistics with SAS' Chuang-Stein, C.; D'Agostino, R. (2005) SAS Publishing (Cary, NC).

  • Molenberghs G, Beunkens C, Jansen I, Thijs H, Verbeke G, Kenward MG, Van Steen K, Analysis of incomplete data. In 'SAS System for Clinical Trials II' Dmitrienko, A.(2005) SAS Publishing (Cary, NC).

Based on the papers:

Van Steen K, Molenberghs G, Verbeke G, Thijs H (2001) A Local Influence Approach to Sensitivity Analysis of Incomplete Longitudinal Ordinal Data, Statistical Modelling: An International Journal, 1: 125-142.

Jansen I, Molenberghs G, Aerts M, Thijs H, Van Steen K (2003) A Local Influence Approach applied to Binary Data from a Psychiatric Study, Biometrics, 59 (2): 410-419.



  • Laird NM, Kraft P, Lange C, Van Steen K, Testing for association in genetic studies. In: Respiratory Genetics, Eds EK Silverman, SD Shapiro, DA Lomas and ST Weiss (2005) Edward Arnold (Publishers) Ltd, pp. 27-46.

  • Van Steen K, Molenberghs G, Multicollinearity, Published in Encyclopedia of Biopharmaceutical Statistics / Shein-Chung Chow [edit.], (2004) ISBN: 0-8247-4263-X.




  • Van Steen K, Molenberghs G, Multivariate and multidimensional analysis, In: Biometrics / Wilson S. [edit.], Oxford, Eolss, (2003).-www.eolss.net.



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